Comparative Transcriptome Analysis Providing Resistance Mechanism of <i>Aspergillus oryzae</i> Under Arsenate Stress

The molecular resistance mechanism of Aspergillus oryzae (A. oryzae) under arsenate (As(V)) stress was investigated by comparative transcriptome analysis. In total, 4911 differentially expressed genes (DEGs) A. were detected As(V) stress, including 2103 up-regulated and 2808 down-regulated genes. Genes induced involved in metal ion binding transportation, redox homeostasis, efflux carrier, DNA repair, volatilization, etc. Moreover, eight selected for qRT-PCR verification, their trends consistent with RNA-Seq analysis, which proved that analysis efficient reliable. results indicated the extracellular intracellular synergistic mechanisms contributed to improvement As (V).